Every living being needs to fight off other
living beings that want to feast on them.​Every living being needs to fight off other
living beings that want to feast on them.​
Every living being needs to fight off other
living beings that want to feast on them.​
So as multicellular life evolved over billions of
years, it came up with ways to defend itself.​So as multicellular life evolved over billions of
years, it came up with ways to defend itself.​
So as multicellular life evolved over billions of
years, it came up with ways to defend itself.​
Today humans have a sophisticated defense network,​Today humans have a sophisticated defense network,​Today humans have a sophisticated defense network,​like physical barriers, defense cells, and weapons factories.​like physical barriers, defense cells, and weapons factories.​like physical barriers, defense cells, and weapons factories.​But one of the most important defenses
of our body is largely unknown:​But one of the most important defenses
of our body is largely unknown:​
But one of the most important defenses
of our body is largely unknown:​
The Complement System​The Complement System​The Complement System​It evolved over 700 million years ago and
is an army of over 30 different proteins​It evolved over 700 million years ago and
is an army of over 30 different proteins​
It evolved over 700 million years ago and
is an army of over 30 different proteins​
that work together in a complex
and elegant dance to stop intruders.​that work together in a complex
and elegant dance to stop intruders.​
that work together in a complex
and elegant dance to stop intruders.​
All in all, about 15 quintillion of them are saturating
every fluid in your body right now.​All in all, about 15 quintillion of them are saturating
every fluid in your body right now.​
All in all, about 15 quintillion of them are saturating
every fluid in your body right now.​
Guided by nothing but chemistry,​Guided by nothing but chemistry,​Guided by nothing but chemistry,​these proteins are one of the most
effective weapons we have against invaders.​these proteins are one of the most
effective weapons we have against invaders.​
these proteins are one of the most
effective weapons we have against invaders.​
Many other parts of the immune system are just
tools to activate the Complement System.​Many other parts of the immune system are just
tools to activate the Complement System.​
Many other parts of the immune system are just
tools to activate the Complement System.​
But it’s also really dangerous.​But it’s also really dangerous.​But it’s also really dangerous.​Imagine having trillions of little bombs inside
your blood that could go off at any moment.​Imagine having trillions of little bombs inside
your blood that could go off at any moment.​
Imagine having trillions of little bombs inside
your blood that could go off at any moment.​
So our cells use numerous mechanisms to prevent​
​complement from accidentally attacking ​​them​.​So our cells use numerous mechanisms to prevent​
​complement from accidentally attacking ​​them​.​
So our cells use numerous mechanisms to prevent​
​complement from accidentally attacking ​​them​.​
Okay, what exactly does it do
and what makes it so dangerous?​Okay, what exactly does it do
and what makes it so dangerous?​
Okay, what exactly does it do
and what makes it so dangerous?​
In a nutshell, The Complement System does three things:​In a nutshell, The Complement System does three things:​In a nutshell, The Complement System does three things:​it cripples enemies, it activates the immune system,
and it rips holes in things until they die.​it cripples enemies, it activates the immune system,
and it rips holes in things until they die.​
it cripples enemies, it activates the immune system,
and it rips holes in things until they die.​
But, how?​But, how?​But, how?​After all, these are mindless proteins randomly
drifting around without will or direction.​After all, these are mindless proteins randomly
drifting around without will or direction.​
After all, these are mindless proteins randomly
drifting around without will or direction.​
Well, this is actually part of the strategy.​Well, this is actually part of the strategy.​Well, this is actually part of the strategy.​Complement proteins float around in a sort-of passive mode.​Complement proteins float around in a sort-of passive mode.​Complement proteins float around in a sort-of passive mode.​They do nothing, until they get activated and change their shape.​They do nothing, until they get activated and change their shape.​They do nothing, until they get activated and change their shape.​In the world of proteins, your shape
determines what you can and cannot do.​In the world of proteins, your shape
determines what you can and cannot do.​
In the world of proteins, your shape
determines what you can and cannot do.​
Because shape determines what
you can interact with and in what way.​Because shape determines what
you can interact with and in what way.​
Because shape determines what
you can interact with and in what way.​
For example, in your passive shape you might do nothing.​For example, in your passive shape you might do nothing.​For example, in your passive shape you might do nothing.​In your active shape, however, you might, for
example, change the shape of other proteins​In your active shape, however, you might, for
example, change the shape of other proteins​
In your active shape, however, you might, for
example, change the shape of other proteins​
activating them so they can activate others.​activating them so they can activate others.​activating them so they can activate others.​Mechanisms like this one can start
cascades that spread very quickly.​Mechanisms like this one can start
cascades that spread very quickly.​
Mechanisms like this one can start
cascades that spread very quickly.​
Imagine the complement proteins as being like
millions of matches very close together.​Imagine the complement proteins as being like
millions of matches very close together.​
Imagine the complement proteins as being like
millions of matches very close together.​
Once one catches fire, it ignites the ones around it.​Once one catches fire, it ignites the ones around it.​Once one catches fire, it ignites the ones around it.​They ignite more and suddenly you have a big fire.​They ignite more and suddenly you have a big fire.​They ignite more and suddenly you have a big fire.​To show the actual mechanisms of The Complement
System is a tad complicated and overwhelming.​To show the actual mechanisms of The Complement
System is a tad complicated and overwhelming.​
To show the actual mechanisms of The Complement
System is a tad complicated and overwhelming.​
So, we’ll simplify here.​So, we’ll simplify here.​So, we’ll simplify here.​Now, let’s imagine you cut yourself
and a bunch of bacteria enter the wound​Now, let’s imagine you cut yourself
and a bunch of bacteria enter the wound​
Now, let’s imagine you cut yourself
and a bunch of bacteria enter the wound​
and make it into the surrounding tissue.​and make it into the surrounding tissue.​and make it into the surrounding tissue.​Our complement attack begins with C3.​Our complement attack begins with C3.​Our complement attack begins with C3.​C3 is the first match, the initial spark that will start our fire.​C3 is the first match, the initial spark that will start our fire.​C3 is the first match, the initial spark that will start our fire.​And to do that, C3 needs to switch from passive to active.​And to do that, C3 needs to switch from passive to active.​And to do that, C3 needs to switch from passive to active.​How this happens is complex, but
let’s just say it can happen randomly​How this happens is complex, but
let’s just say it can happen randomly​
How this happens is complex, but
let’s just say it can happen randomly​
through other complement proteins that
bind to enemies or through antibodies.​through other complement proteins that
bind to enemies or through antibodies.​
through other complement proteins that
bind to enemies or through antibodies.​
All you really need to know is that
C3 breaks into two smaller proteins,​All you really need to know is that
C3 breaks into two smaller proteins,​
All you really need to know is that
C3 breaks into two smaller proteins,​
C3a and C3b, that are now activated.​C3a and C3b, that are now activated.​C3a and C3b, that are now activated.​One of these parts, the C3b protein, is like a seeker
missile specialized in bacteria, fungi, and viruses.​One of these parts, the C3b protein, is like a seeker
missile specialized in bacteria, fungi, and viruses.​
One of these parts, the C3b protein, is like a seeker
missile specialized in bacteria, fungi, and viruses.​
It has a fraction of a second to find a victim
or it will be neutralized by water molecules.​It has a fraction of a second to find a victim
or it will be neutralized by water molecules.​
It has a fraction of a second to find a victim
or it will be neutralized by water molecules.​
If C3b does find a target, it anchors itself very
tightly to its surface and doesn’t let go.​If C3b does find a target, it anchors itself very
tightly to its surface and doesn’t let go.​
If C3b does find a target, it anchors itself very
tightly to its surface and doesn’t let go.​
By doing so, the protein changes its shape again.​By doing so, the protein changes its shape again.​By doing so, the protein changes its shape again.​In its new shape, it’s now able to grab
other proteins and start a small cascade,​In its new shape, it’s now able to grab
other proteins and start a small cascade,​
In its new shape, it’s now able to grab
other proteins and start a small cascade,​
changing its shape multiple times,
adding other complement proteins to itself.​changing its shape multiple times,
adding other complement proteins to itself.​
changing its shape multiple times,
adding other complement proteins to itself.​
Finally, it transforms itself into a recruiting
platform known as C3 Convertase.​Finally, it transforms itself into a recruiting
platform known as C3 Convertase.​
Finally, it transforms itself into a recruiting
platform known as C3 Convertase.​
This platform is an expert at activating more
C3 proteins that start the whole cycle anew.​This platform is an expert at activating more
C3 proteins that start the whole cycle anew.​
This platform is an expert at activating more
C3 proteins that start the whole cycle anew.​
An amplification loop begins.​An amplification loop begins.​An amplification loop begins.​Soon, thousands of proteins cover the bacteria.​Soon, thousands of proteins cover the bacteria.​Soon, thousands of proteins cover the bacteria.​For the bacteria, this is very bad.​For the bacteria, this is very bad.​For the bacteria, this is very bad.​It can cripple the bacteria and make
them helpless, or slow them down.​It can cripple the bacteria and make
them helpless, or slow them down.​
It can cripple the bacteria and make
them helpless, or slow them down.​
Imagine being covered by thousands of flies.​Imagine being covered by thousands of flies.​Imagine being covered by thousands of flies.​But, there’s more.​But, there’s more.​But, there’s more.​Do you remember the other part of C3—the C3a protein?​Do you remember the other part of C3—the C3a protein?​Do you remember the other part of C3—the C3a protein?​C3a is like a distress beacon.​C3a is like a distress beacon.​C3a is like a distress beacon.​Thousands of them flood away from
the site of battle screaming for attention.​Thousands of them flood away from
the site of battle screaming for attention.​
Thousands of them flood away from
the site of battle screaming for attention.​
Passive immune cells notice the C3a proteins,​Passive immune cells notice the C3a proteins,​Passive immune cells notice the C3a proteins,​and awaken from their slumber to follow
the protein tracks to the site of infection.​and awaken from their slumber to follow
the protein tracks to the site of infection.​
and awaken from their slumber to follow
the protein tracks to the site of infection.​
The more alarm proteins they encounter,
the more aggressive they get.​The more alarm proteins they encounter,
the more aggressive they get.​
The more alarm proteins they encounter,
the more aggressive they get.​
This way, complement guides reinforcements
exactly to the place where they’re needed the most.​This way, complement guides reinforcements
exactly to the place where they’re needed the most.​
This way, complement guides reinforcements
exactly to the place where they’re needed the most.​
So far, the complement has slowed
down the invaders and called for help.​So far, the complement has slowed
down the invaders and called for help.​
So far, the complement has slowed
down the invaders and called for help.​
Now, it’s beginning to actively help to kill the enemy.​Now, it’s beginning to actively help to kill the enemy.​Now, it’s beginning to actively help to kill the enemy.​The first immune cells to arrive at the battlefield are ​​phagocytes​.​The first immune cells to arrive at the battlefield are ​​phagocytes​.​The first immune cells to arrive at the battlefield are ​​phagocytes​.​Which means, cells that swallow you whole, trap
you in a tiny prison, and then kill you with acid.​Which means, cells that swallow you whole, trap
you in a tiny prison, and then kill you with acid.​
Which means, cells that swallow you whole, trap
you in a tiny prison, and then kill you with acid.​
But, to swallow an enemy, they need to grab it first.​But, to swallow an enemy, they need to grab it first.​But, to swallow an enemy, they need to grab it first.​Which is not easy because bacteria prefer
not to be grabbed and are sort-of slippery.​Which is not easy because bacteria prefer
not to be grabbed and are sort-of slippery.​
Which is not easy because bacteria prefer
not to be grabbed and are sort-of slippery.​
But now, the complement that has
anchored itself to the bacteria​But now, the complement that has
anchored itself to the bacteria​
But now, the complement that has
anchored itself to the bacteria​
acts as a sort-of glue that makes it easy
for the immune cells to catch their victims.​acts as a sort-of glue that makes it easy
for the immune cells to catch their victims.​
acts as a sort-of glue that makes it easy
for the immune cells to catch their victims.​
But it gets even better.​But it gets even better.​But it gets even better.​Imagine being covered in flies again.​Imagine being covered in flies again.​Imagine being covered in flies again.​Now, imagine them turning into wasps.​Now, imagine them turning into wasps.​Now, imagine them turning into wasps.​Another cascade is about to begin.​Another cascade is about to begin.​Another cascade is about to begin.​On the surface of a bacteria, the C3
recruitment platform changes its shape again​On the surface of a bacteria, the C3
recruitment platform changes its shape again​
On the surface of a bacteria, the C3
recruitment platform changes its shape again​
and begins to recruit new proteins.​and begins to recruit new proteins.​and begins to recruit new proteins.​Together, they begin the construction of a bigger
structure: a Membrane Attack Complex.​Together, they begin the construction of a bigger
structure: a Membrane Attack Complex.​
Together, they begin the construction of a bigger
structure: a Membrane Attack Complex.​
Piece-by-piece, new proteins shaped like long spears
anchor themselves deep into the bacteria’s membranes,​Piece-by-piece, new proteins shaped like long spears
anchor themselves deep into the bacteria’s membranes,​
Piece-by-piece, new proteins shaped like long spears
anchor themselves deep into the bacteria’s membranes,​
until they rip a hole into them that can’t be closed again.​until they rip a hole into them that can’t be closed again.​until they rip a hole into them that can’t be closed again.​Fluids rush into the bacteria and their insides spill out.​Fluids rush into the bacteria and their insides spill out.​Fluids rush into the bacteria and their insides spill out.​They bleed to death.​They bleed to death.​They bleed to death.​The remaining bacteria are maimed
and distracted by the complement,​The remaining bacteria are maimed
and distracted by the complement,​
The remaining bacteria are maimed
and distracted by the complement,​
and quickly taken care of by the arriving immune cells.​and quickly taken care of by the arriving immune cells.​and quickly taken care of by the arriving immune cells.​The invasion has been nipped in the bud before
it had the opportunity to become dangerous.​The invasion has been nipped in the bud before
it had the opportunity to become dangerous.​
The invasion has been nipped in the bud before
it had the opportunity to become dangerous.​
You probably didn’t even notice it.​You probably didn’t even notice it.​You probably didn’t even notice it.​But while bacteria are not happy about complement,​But while bacteria are not happy about complement,​But while bacteria are not happy about complement,​the enemies it might be the most
useful against are actually viruses.​the enemies it might be the most
useful against are actually viruses.​
the enemies it might be the most
useful against are actually viruses.​
Viruses have one problem:
they need to travel from cell to cell.​Viruses have one problem:
they need to travel from cell to cell.​
Viruses have one problem:
they need to travel from cell to cell.​
Outside of cells, they’re basically hoping to randomly
bump against a cell to infect by pure chance.​Outside of cells, they’re basically hoping to randomly
bump against a cell to infect by pure chance.​
Outside of cells, they’re basically hoping to randomly
bump against a cell to infect by pure chance.​
Here, they’re completely defenseless.​Here, they’re completely defenseless.​Here, they’re completely defenseless.​And here, complement is able to intercept and cripple them,​And here, complement is able to intercept and cripple them,​And here, complement is able to intercept and cripple them,​so they become harmless and guide
the immune system to devour them.​so they become harmless and guide
the immune system to devour them.​
so they become harmless and guide
the immune system to devour them.​
Without complement, virus
infections would be a lot more deadly.​Without complement, virus
infections would be a lot more deadly.​
Without complement, virus
infections would be a lot more deadly.​
But wait, if we have such an effective
weapon, why do we ever get sick?​But wait, if we have such an effective
weapon, why do we ever get sick?​
But wait, if we have such an effective
weapon, why do we ever get sick?​
The problem is that in a war, both sides adapt.​The problem is that in a war, both sides adapt.​The problem is that in a war, both sides adapt.​For example, when the ​​vaccinia virus​infects a cell,​For example, when the ​​vaccinia virus​infects a cell,​For example, when the ​​vaccinia virus​infects a cell,​it forces it to produce a protein
that shuts complement activation down.​it forces it to produce a protein
that shuts complement activation down.​
it forces it to produce a protein
that shuts complement activation down.​
This way, the virus creates safe
zones around the cells it infects.​This way, the virus creates safe
zones around the cells it infects.​
This way, the virus creates safe
zones around the cells it infects.​
When it kills them, and tries to infect more,
it has a higher chance of being successful.​When it kills them, and tries to infect more,
it has a higher chance of being successful.​
When it kills them, and tries to infect more,
it has a higher chance of being successful.​
Or some bacteria, for example, can grab certain molecules
from the blood that keep the complement system calm​Or some bacteria, for example, can grab certain molecules
from the blood that keep the complement system calm​
Or some bacteria, for example, can grab certain molecules
from the blood that keep the complement system calm​
and make themselves invisible.​and make themselves invisible.​and make themselves invisible.​So the complement system,
while being extremely important,​So the complement system,
while being extremely important,​
So the complement system,
while being extremely important,​
is only one player in the complex and beautiful
organization that is our immune system.​is only one player in the complex and beautiful
organization that is our immune system.​
is only one player in the complex and beautiful
organization that is our immune system.​
A beautiful example of how many
mindless things can do smart things together.​A beautiful example of how many
mindless things can do smart things together.​
A beautiful example of how many
mindless things can do smart things together.​
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Tiny Bombs in your Blood – The Complement System
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100 thoughts on “Tiny Bombs in your Blood – The Complement System

  • July 26, 2019 at 3:21 pm
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    Our Complement System is super complex and fascinating and we can’t get enough of it – so we also made a poster and postcards with its core workings step by step.
    Get it here: http://shop.kurzgesagt.org

    Reply
  • August 31, 2019 at 10:38 pm
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    1:02 killer queen’s third bomb, bites za dusto

    Reply
  • August 31, 2019 at 10:55 pm
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    cool

    Reply
  • August 31, 2019 at 11:35 pm
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    What I learned: I'm just a giant vessel for my proteins

    Reply
  • August 31, 2019 at 11:37 pm
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    Our protein's civilization is more advanced than our own

    Reply
  • September 1, 2019 at 12:22 am
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    That’s probably how acupuncture work…

    Reply
  • September 1, 2019 at 5:22 am
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    I'm sick and I'm watching this to see how my immune system is doing 🤒😷😊

    Reply
  • September 1, 2019 at 7:45 am
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    This kind of method can be use in future to explore the space

    Reply
  • September 1, 2019 at 9:17 am
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    FIRST MATTER: In every facet of the motion of all particles the light of Divine unity shines like the sun. For as is proved briefly in the First Indication of the Tenth Word and in detail in the Twenty-Second Word, if every particle is not an official of God acting with His permission and under His authority, and if it is not undergoing change within His knowledge and power, then every particle must have infinite knowledge and limitless power; it must have eyes that see everything, a face that looks to all things, and authority over all things. For every particle of the elements acts, or can act, in an orderly fashion in all animate beings. But the order within things and laws according to which they are formed differ from one thing to the next. If their order was not known to the particles, the particles could not act, or even if they could act, they could not act without error. In which case, the particles which are performing their duties in beings are either acting with the permission and at the command, and within the knowledge and at the will, of the owner of an all-encompassing knowledge, or they themselves must have such an all-encompassing knowledge and power. Yes, all particles of air can enter the bodies of all animate beings, the fruits of all flowers, and the structures of all leaves. They can act within them, although the way the beings are formed is all different and their order and systems quite distinct. As though the factory of a fig was a loom for weaving cloth and the factory of a pomegranate, a machine for producing sugar, and so on; the programmes of their structures and bodies all differ from each other. A particle of air, then, enters or can enter all of them. It takes up its position and acts in a wise and masterly fashion without error. And on completion of its duty it departs. A mobile particle of mobile air, therefore, either must know the forms, shapes, measures, and formations with which plants and animals, and even fruits and flowers, are clothed, or else it must be an official acting under the command and will of one who does know. Similarly with a stationary particle of stationary earth: since it has the ability to be the means and place of cultivation for all the seeds of all flowering plants and fruit-bearing trees, either there must be in the particle itself or in the handful of soil that is its little house immaterial machinery and factories in good working order to the number of the varieties of the trees and plants, and flowers and fruits in fact, it is in every single particle that there must be a factory peculiar to it and all the equipment and machinery necessary for the running of the factory or else it must have a miraculous knowledge that knows all things about all things and a miracle-working power that creates everything from nothing; or, those duties are performed at the command and with the permission of One Who is Knowing of All Things, and through the power and might of One Who is Absolutely Powerful over All Things. If an untrained and inexperienced, common, ordinary, and blind man was to go to Europe and in all the factories there to work at all the trades and crafts in perfect and masterly fashion, and if he was to display a wise and artistic skill to such a degree that it left everyone speechless with amazement, anyone with a grain of consciousness would know that the man was not acting on his own initiative, but that a master of all trades was teaching him and causing him to work. And if there was a blind and impotent man who lived in a simple little house and was unable even to rise from his place, and if small fragments of stone, and bits and pieces of material like bone and cotton were to enter his little house and then sacks of sugar, bales of cloth, crates of jewelry, finely-made clothes encrusted with jewels, and delicious foods were to emerge, would anyone with a grain of intelligence not say: "That man is a wretched doorkeeper or merely a latch on the door of the factory of a wondrous miracle-working being, which is the source of his miracles"? In exactly the same way, the motion and duties of particles of air in plants and trees, and blossom and fruit, all of which are missives of the Eternally Besought One, antique dominical works of art, miracles of power, and wonders of wisdom, indicate that the particles are acting under the command and at the will of an All-Wise and Glorious Maker, an All-Generous and Beauteous Creator. Particles of earth, also, since they are the source and means for the shoots and plants produced by seeds, each of which is a different factory and workbench, a different printing-press, treasury, and antique, a different manifesto proclaiming the Glorious Maker's Names and ode hymning His perfections, it is as definite as two plus two equalling four that the particles of earth are acting at the command, with the permission, and through the will and power of an All-Glorious Maker Who is Lord of the command of "Be!" and it is, {[*]: Qur'an, 36:82, etc.} and to Whose command everything is subjugated. In this we believe. Risale-i Nur Collection 572 – Bediüzzaman Said Nursi

    Reply
  • September 1, 2019 at 9:18 am
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    SEVENTH FLASH
    Look! With little difficulty you can see the seals of the Single, Eternally Besought One on the page of the earth, so raise your head, open your eyes, and look too at the great book of the universe. You will see that on it as a whole a stamp of unity is read out which is as clear as it is big. For like the components of a factory or members of a palace or town, these beings support one another, stretch out their hands to assist one another, and answer the needs and requests of one another, saying: "Here I am, at your service!" Assisting one another, they work together in order. Joining efforts, they serve animate beings. Co-operating and turned a single goal, they obey an All-Wise Disposer. They conform to a rule of mutual assistance which is in force from the sun and moon, night and day, and winter and summer, to plants coming to the assistance of hungry and needy animals, and animals hastening to the assistance of weak, noble men, and even nutritious substances flying to assist delicate, weak infants and fruits, and particles of food passing to the assistance of the cells of the body. They show to anyone who is not altogether blind that they are acting through the strength of a single, most generous Nurturer, and at the command of a single most wise Disposer.
    Thus, on the one hand this mutual support and assistance, this answering one another's needs, this mutual embracing, this subjugation, this order, testify decisively that beings are administered and organized by a single Disposer and are being impelled and directed by a single Nurturer. And on the other hand, this perfect grace within the universal wisdom to be seen plainly in the art of things; and the all-embracing mercy which shines within the providence; and the sustenance spread over that mercy and scattered so as to answer the needs of all living beings needy for sustenance; -these form a stamp of Divine unity so brilliant that anyone whose mind is not altogether extinguished will understand it and anyone who is not altogether blind will see it.
    Yes, a veil of wisdom demonstrating intention, consciousness, and will, has covered the whole universe, and upon that veil of wisdom has been spread a veil of grace and favour exhibiting beneficence, adornment, embellishment, and benevolence; and over that adorned veil of favour a garment of mercy displaying flashes of making known and loved, of bestowal and the granting of gifts has enveloped the universe; and spread over that illuminated veil of universal mercy is a table of general provisions showing kindness and bestowal and benevolence and perfect compassion and fine nurturing and dominical favour.
    Yes, all beings from particles to suns, whether individuals or species, or large or small, have been clothed in a magnificent shirt of wisdom embroidered with fruits and aims, benefits and purposes. And over the wisdom-displaying shirt, a garment of favour embroidered with flowers of grace and beneficence has been cut out in accordance with the stature of things; and over that ornamented garment of favour, a general table of sustenance has been set up, lit up with flashes of love, bestowal, affection, and the granting of gifts, to which the decorations of mercy have been attached, and which, together with bestowing those illuminated and jewel-encrusted decorations, is sufficient for all the groups of living beings on the face of the earth, and meets all their needs. Thus, this matter points to an All-Glorious Provider Who is All-Wise, All-Generous, and All-Compassionate, and shows Him as clearly as the sun.
    Is that so? Is everything in need of sustenance?
    Yes, like individual beings are in need of sustenance and all the necessities to continue their lives, we see that all the beings in the world, and especially living beings, whether universal or particular, wholes or parts, have many desires and needs, material and otherwise, for their existence, their lives, and the continuation of their lives. But their wants and needs are for such things that their hands cannot reach the least of them and their power is insufficient for the smallest of them. Yet, we see that all their wishes and material and immaterial sustenance is given to them From where he could not imagine, {[*]: Qur'an, 65:3.} from unhoped for places, with perfect order, at the appropriate time, in a suitable fashion, with perfect wisdom. And so, does this want and need of creatures and this manner of unseen help and assistance not show an All-Wise and Glorious Nurturer, an All-Compassionate Beauteous Disposer?
    Risale-i Nur Collection Words – 309 Bediüzzaman Said Nursi (R. A)

    Reply
  • September 1, 2019 at 9:35 am
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    Hey kurzgesagt, I really love your Immunology Videos and hope you guys would do it, like what would the immune system do when there is a worm infection.

    Reply
  • September 1, 2019 at 11:46 am
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    so if the proteins make it to the infection by pure chance technecly if someone is REALLY unlucky the proteins that float around will never make it to the disese and they will die

    Reply
  • September 1, 2019 at 12:55 pm
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    part 3, please

    Reply
  • September 1, 2019 at 1:02 pm
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    Despite all this people are still being killed by influenza

    Reply
  • September 1, 2019 at 1:12 pm
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    Fagocyte

    Reply
  • September 1, 2019 at 2:00 pm
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    Dont complement me
    Complement guests

    r/MeIRL

    Reply
  • September 1, 2019 at 2:10 pm
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    Dab

    Reply
  • September 1, 2019 at 3:44 pm
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    자막하신 분 ㅋㅋㅋㅋㅋㅋㅋㅋㅋㅋ 우라늄은 초록색이 아니얔ㅋㅋㅋㅋㅋㅋㅋㅋㅋㅋ

    Reply
  • September 1, 2019 at 3:51 pm
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    What Kurzgesagt says: …many mindless things can do smart things together.

    What Kurzgesagt thinks: I'M TALKING TO YOU, HUMANS

    Reply
  • September 1, 2019 at 3:53 pm
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    If only the C3 proteins were called C4s. Because you said that there are trillions of little bombs in our blood that can go off at any moment.

    Reply
  • September 1, 2019 at 4:09 pm
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    4:38 Yeah, just like waking a British person up from their sleep

    Reply
  • September 1, 2019 at 6:05 pm
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    At 0:31 CR3 has a gun

    Reply
  • September 1, 2019 at 6:27 pm
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    Call of Immunity: Cell Warfare

    Reply
  • September 1, 2019 at 7:26 pm
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    Brain: The bacteria are rage, ruthless, with out mercy. But you Complement system you will be worse, Rip and tear until they are gone.

    Reply
  • September 1, 2019 at 7:38 pm
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    Clickbait is only acceptable when Kurzgesagt does it 🙂

    Reply
  • September 1, 2019 at 7:47 pm
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    all this shit and i still have a cold

    Reply
  • September 1, 2019 at 8:34 pm
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    That art style long satisfied grunt

    Reply
  • September 1, 2019 at 9:28 pm
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    "Is a tad bit complicated"

    Just like the ocean has a tad bit of water

    Reply
  • September 1, 2019 at 10:45 pm
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    imagine if said bombs were literal

    Reply
  • September 2, 2019 at 1:13 am
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    I loved this

    Reply
  • September 2, 2019 at 1:43 am
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    "The bacteria bleeds to death" so what if the bacteria had blood types and millions would die in our blood? We would he screwed because we can only take out blood type

    Reply
  • September 2, 2019 at 2:05 am
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    New season of Cells at Work looks good

    Reply
  • September 2, 2019 at 2:33 am
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    And people say all this came by an accident over billions of year. Evolution my ass.

    Reply
  • September 2, 2019 at 2:48 am
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    killer queen.mp4

    Reply
  • September 2, 2019 at 3:20 am
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    When this lego set coming out

    Reply
  • September 2, 2019 at 4:39 am
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    Dry fasting cures everything

    Reply
  • September 2, 2019 at 5:56 am
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    I’m pretty sure this is the plot to zero escape.

    Reply
  • September 2, 2019 at 7:07 am
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    Whot its so nice how it woks

    Reply
  • September 2, 2019 at 7:39 am
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    Bacteria : See's a compliment protein Oh no… It's my end

    Viruses : NOPE NOPE NOPE NOPE NOPE NOPE NOPE NOPE NOPE NOPE NOPE NOPE NOPE NOPE NOPE NOPE NOPE NOPE NOPE NOPE GET ME OUT OF HERE!

    Reply
  • September 2, 2019 at 8:12 am
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    This is so damn mind blowing ugh!!!

    Reply
  • September 2, 2019 at 8:59 am
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    Your videos are better than ASMRs

    Reply
  • September 2, 2019 at 11:58 am
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    super sophisticated and complex system of the body that ensures human survival
    school :

    some dumb table with weird letters and numbers most scholars don't care about
    school : I'LL TAKE YOUR ENTIRE STOCK

    Reply
  • September 2, 2019 at 12:37 pm
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    A very lovely video :*:*:*:*:*:*

    Reply
  • September 2, 2019 at 3:00 pm
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    so cool

    Reply
  • September 2, 2019 at 4:43 pm
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    So, when's the manga/anime coming out?

    Reply
  • September 2, 2019 at 5:12 pm
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    GOD BLESS EVERYONE WHO IS THERE🙏

    Reply
  • September 2, 2019 at 8:10 pm
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    Me: looking at my arm after the video.

    Also me: I HAVE THE POWERRRRRRRRR

    Reply
  • September 2, 2019 at 8:24 pm
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    ne demek gülüm

    Reply
  • September 2, 2019 at 10:49 pm
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    Killer Queen is here!

    Reply
  • September 2, 2019 at 11:41 pm
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    I bet there is a protein out there named: c418

    Reply
  • September 3, 2019 at 1:51 am
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    If we are to compare the complement system to war games, they are the first line of defense defending the front lines with small but deadly weapons. While the phagocytes are the first reinforcements

    Reply
  • September 3, 2019 at 2:44 am
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    my viruses and bacteria: ahh… Good idea… 6:53 – 7:16

    Reply
  • September 3, 2019 at 7:03 am
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    Ohhh this answers spontaneous human combustion huh??

    Reply
  • September 3, 2019 at 10:02 am
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    0:23
    He said the line..
    Hehehehehehehe

    Reply
  • September 3, 2019 at 10:26 am
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    Friend : Aww!!…
    Me : What?
    Friend : I accidentally cut my finger
    Me : (sees the sky seriously)
    Friend : What?
    Me : The war is coming

    Reply
  • September 3, 2019 at 10:39 am
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    so we can be not healthy

    iam in confusion

    Reply
  • September 3, 2019 at 12:07 pm
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    Phagocytes? Looks like Macrophage

    YAA IM ON THE FIRST IMMUNE SYSTEM

    Reply
  • September 3, 2019 at 1:25 pm
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    Kurzgesagt: Flies over your face
    Me: Oh no
    Kurzgesagt: Wasps
    Me: Please no
    Kurzgesagt: Mosquitoes
    Me: AHHH HELL NAAAWWWW

    Reply
  • September 3, 2019 at 4:01 pm
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    nope nope nope nope

    Reply
  • September 3, 2019 at 4:28 pm
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    We need more IMMUNE SYSTEM Videos!

    Reply
  • September 3, 2019 at 4:39 pm
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    1! 2! 3,4!
    We, are, cells at work!

    Reply
  • September 3, 2019 at 5:04 pm
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    DO MORE

    Reply
  • September 3, 2019 at 5:04 pm
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    Immune system vids

    Reply
  • September 3, 2019 at 6:05 pm
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    "Which are basically cells that swallow you whole and then melt you with acid."

    0h w0w

    Reply
  • September 3, 2019 at 6:50 pm
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    wow

    Reply
  • September 3, 2019 at 7:10 pm
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    Virgin Cells nice

    Reply
  • September 3, 2019 at 7:42 pm
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    Kurzgesagt promised us an immune system app 3 years ago =p, but even without it, the animation and explanation are incredible, continue the good work !

    Reply
  • September 3, 2019 at 9:42 pm
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    Spontaneous human combustion confirmed @ 0:57

    Reply
  • September 3, 2019 at 11:22 pm
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    I have an entire millitary inside my body, and i am proud of that

    Reply
  • September 4, 2019 at 4:02 am
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    I swear to god this channel will answer every question in the universe

    Reply
  • September 4, 2019 at 4:57 am
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    To be honest , This is The best channel on YouTube since the existence oh humanity .

    Reply
  • September 4, 2019 at 5:21 am
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    This is Killer Queens 4th bomb

    Reply
  • September 4, 2019 at 5:36 am
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    Do some More I love it😀😍😍

    Reply
  • September 4, 2019 at 5:36 am
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    It’s cool how there is an avengers movie in my body

    Reply
  • September 4, 2019 at 5:54 am
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    Power Rangers Assemble!

    Reply
  • September 4, 2019 at 9:02 am
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    (Something pierces my skin)
    My proteins: this is an avengers level threat

    Reply
  • September 4, 2019 at 10:03 am
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    1:00 killer queen has already touched your blood

    Reply
  • September 4, 2019 at 10:39 am
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    Bacteria enters the body
    Complement System: Autobots Roll out

    Reply
  • September 4, 2019 at 11:07 am
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    Can you make one one smallpox? Why it was so deadly? What countermeasure did it have to beat our system?

    Reply
  • September 4, 2019 at 11:25 am
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    So when the hook came off (1:49) It is activated so its a grenade

    Reply
  • September 4, 2019 at 12:51 pm
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    bruh this is some serious world war crap wow

    Reply
  • September 4, 2019 at 4:59 pm
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    it's just awesome.

    Reply
  • September 4, 2019 at 6:36 pm
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    Bacteria is like zombies and our skin is the wall

    Reply
  • September 4, 2019 at 6:57 pm
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    SO basically: a war in my body happens every time an infection enters?

    Reply
  • September 4, 2019 at 7:13 pm
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    Thank you for this beautiful video

    Reply
  • September 4, 2019 at 7:52 pm
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    Now, turn this into a friggin video game

    Reply
  • September 5, 2019 at 12:03 am
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    Phagocytes 😀

    Reply
  • September 5, 2019 at 1:39 am
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    Your the best YouTube channel ever!😀😄😄

    Reply
  • September 5, 2019 at 5:17 am
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    i really wish i could afford to make donations

    Reply
  • September 5, 2019 at 11:50 am
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    C4? We have c4 in our body ? damn

    Reply
  • September 5, 2019 at 11:55 am
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    Gets pricked by a needle
    Proteins: Now that's an avengers level threat

    Reply
  • September 5, 2019 at 12:31 pm
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    Boring more ant wars

    Reply
  • September 5, 2019 at 3:31 pm
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    Watching this video while having a really bad cold is really comforting !

    Reply
  • September 5, 2019 at 5:35 pm
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    KILLA QUEEN

    Reply
  • September 5, 2019 at 7:51 pm
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    It I can like this I would like it more than 10x

    Reply
  • September 5, 2019 at 7:53 pm
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    This sounds like an awesome video game

    Reply
  • September 5, 2019 at 8:50 pm
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    5:15 "C3B acts as a sort of glue that makes it easy for the immune cells to catch their victims"
    Glue? Really?? 'Velcro' should've been the much more obvious comparison, here, surely? Come on, guys! It's 2019 – get it together! 눈_눈

    Reply
  • September 6, 2019 at 2:51 am
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    Excelentes videos pero mi visualizacion se centra mas en los subtitulos y no logro captar la animacion deberian crear un canal con el mismo contenido pero en español ayudaria mucho en ese sentido espero y lo tomen en cuenta
    Espero y esten de acuerdo conmigo

    Reply
  • September 6, 2019 at 5:47 am
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    15,000,000,000,000,000 FIFTEEN QUINTILLION WHAT THE GODZILLA

    Reply

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